Article
A vascular disrupting agent overcomes tumor multidrug resistance by skewing macrophage polarity toward the M1 phenotype.
Cancer letters - 1 Apr 2018
Lei Xueping, Chen Minfeng, Li Xiaobo, Huang Maohua, Nie Qiulin, Ma Nan, Chen Heru, Xu Nanhui, Ye Wencai, Zhang Dongmei
Abstract excerpt
Multidrug resistance (MDR) mediated by ATP-binding cassette (ABC) transporters is the major obstacle for chemotherapeutic success. Although attempts have been made to circumvent ABC transporter-mediated MDR in past decades, there is still no effective agent in clinic. Here, we identified a vascular disrupting agent, Z-GP-DAVLBH, that significantly inhibited the growth of multidrug-resistant human hepatoma...
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