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Article

The anti-hepatitis drug DDB chemosensitizes multidrug resistant cancer cells in vitro and in vivo by inhibiting P-gp and enhancing apoptosis.

Investigational new drugs - 1 Apr 2007

Jin Jing, Sun Hua, Wei Huailing, Liu Gengtao

Abstract excerpt

PURPOSE: DDB (dimethyl-4,4'-dimethoxy-5,6,5'6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate) is a synthetic hepatoprotectant which has been widely used to treat chronic viral hepatitis B patients in China for more than 20 years. In this study, we evaluated DDB as a multidrug resistance (MDR) chemosensitizing agent. METHODS: A panel of sensitive and resistant cancer cell lines were treated with various...

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Identifiers

PMID: 16937080
DOI: 10.1007/s10637-006-9001-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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