Article
[Pharmacological biomodulation in cancer].
Acta cientifica venezolana - 1 Jan 2001
Arvelo F, Merentes E
Abstract excerpt
The discovery of the P-glycoprotein as a mediator of multidrug resistance (MDR) represents one of the most important research accomplishments in antineoplastic pharmacology during the last decade. Demonstration of Pgp in epithelial tissues, untreated and chemotherapeutically pretreated human malignancies, and identification of various agents capable of reversing in vitro resistance has generated enthusiasm for...
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