Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions.

The EMBO journal - 7 Jul 2004

Woods Alison J, White Dominic P, Caswell Patrick T, Norman Jim C

Abstract excerpt

To identify kinases that regulate integrin recycling, we have immunoprecipitated alphavbeta3 integrin from NIH 3T3 fibroblasts in the presence and absence of primaquine (a drug that inhibits receptor recycling and leads to accumulation of integrins in endosomes) and screened for co-precipitating kinases. Primaquine strongly promoted association of alphavbeta3 integrin with PKD1, and fluorescence microscopy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endosomes
Share to Focal Adhesions
Share to Integrin alphaVbeta3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Magnetics

Share to NIH 3T3 Cells

Share to Platelet-Derived Growth Factor

Share to Protein Kinase C

Share to TRPP Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 15192707
DOI: 10.1038/sj.emboj.7600267
PMCID: PMC449777

Genes

PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PKD1/PKCmu promotes alphavbeta3 integrin recycling and delivery to nascent focal adhesions.PMID 15192707Read ↗

Rab-coupling protein coordinates recycling of alpha5beta1 integrin and EGFR1 to promote cell migration in 3D microenvironments.Semantic proximity Read ↗

Protein kinase D1 and the beta 1 integrin cytoplasmic domain control beta 1 integrin function via regulation of Rap1 activation.Semantic proximity Read ↗

Phactr4 influences macrophage lamellipodial structure and dynamics through Arp2/3 complex and Ezrin regulationSemantic proximity Read ↗

Phosphatidylinositol 4-kinase III beta regulates cell shape, migration and Focal Adhesion numberSemantic proximity Read ↗

The kinesin KIF3AC recycles endocytosed integrin to polarize adhesion formation towards the leading edgeSemantic proximity Read ↗

GGA2 and RAB13 promote activity-dependent β1-integrin recyclingSemantic proximity Read ↗

Serines in the Intracellular Tail of Podoplanin (PDPN) Regulate Cell MotilitySemantic proximity Read ↗

SRC-3Δ4 Mediates the Interaction of EGFR with FAK to Promote Cell MigrationSemantic proximity Read ↗

Distinct roles for phosphoinositide 3-kinases γ and δ in malignant B cell migration.Semantic proximity Read ↗

Phosphorylation of actopaxin regulates cell spreading and migration.Semantic proximity Read ↗

Characterization of the role of RILP in cell migration.Semantic proximity Read ↗

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.