Article
Interaction between CD82 and integrin αVβ3 selectively regulates collective movement of tumor cells via endolysosomal trafficking.
Cellular and molecular life sciences : CMLS - 22 Jun 2026
Wang Xue Jun, Richardson Mekel M, Ding Yingjun, Jiang Chao, Liu Songlan, Zhou Bin, Li Shuping, Chen Junxiong, Rubinstein Eric, Hays Franklin A, Mehla Kamiya, Zhang Xin A
Abstract excerpt
Tetraspanin CD82/KAI1 inhibits cell movement and metastasis of malignant tumors, and reduced and lost expressions of CD82 predict worse outcomes of patients with malignant tumors. Here we found that CD82 inhibits both solitary and collective movement of tumor cells. The CD82 YVAA mutation, which affects CD82 trafficking, selectively abrogates CD82-mediated inhibition of collective migration. Cilengitide, at the...
Read the complete abstract on PubMedTopics
- Humans
- Kangai-1 Protein
- Integrin alphaVbeta3
- Cell Movement
- Lysosomes