Article
Class I and II HLA genes are associated with susceptibility and age at onset in Finnish families with type 1 diabetes.
Human heredity - 1 Jan 2004
Pitkäniemi Janne, Hakulinen Timo, Näsänen Jurkka, Tuomilehto-Wolf Eva, Tuomilehto Jaakko
Abstract excerpt
OBJECTIVES: We explored the properties of the long-term survivor model (LTS) in the genetic association studies and studied allelic and haplotypic associations between the age at onset and partially latent susceptibility of type 1 diabetes (T1DM) and Human Leucocyte Antigen (HLA) A, B and DR loci. METHODS: The authors applied the long-term survivor model (LTS) for sibships collected in a population-based registry...
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