Article
Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset. Swedish Childhood Diabetes Study Group.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Jan 2000
Graham J, Kockum I, Sanjeevi C B, Landin-Olsson M, Nyström L, Sundkvist G, Arnqvist H, Blohmé G, Lithner F, Littorin B, Scherstén B, Wibell L, Ostman J, Lernmark A, Breslow N, Dahlquist G
Abstract excerpt
HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in population-based Swedish patients and controls aged 0-34 years. The age dependence of HLA-associated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at onset in the...
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