Article
[The relationship of p53 and the cytotoxicity mediated by TM-TNF-alpha and S-TNF-alpha].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Mar 2004
Zhu Jun, Zheng Fang, Zhang Jian, Xiong Ping, Xu Yong, Li Zhuo-ya
Abstract excerpt
AIM: To explore the relationship of p53 and the cytotoxicity mediated by TM-TNF-alpha and S-TNF-alpha. METHODS: P53 mutation in tumor cell was detected by PCR-SSCP. Wide type p53 expression plasmid was transfected to tumor cells with mutant p53 gene, while the mutant type p53 plasmid to tumor cell with wide type p53 gene.Then,the effects of transfection on the cytotoxicity of two types of TNF were detected....
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