p53 modulation of Fas/Apo-1 mediated apoptosis in a human renal cell carcinoma cell line.

doi:10.3892/ijo.12.2.469

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Article

p53 modulation of Fas/Apo-1 mediated apoptosis in a human renal cell carcinoma cell line.

International journal of oncology - 1 Feb 1998

Miyake H, Hara I, Gohji K, Arakawa S, Kamidono S

Abstract excerpt

The mutant p53 gene was transfected into ACHN, a wild-type p53-containing human renal cell carcinoma (RCC) cell line. The colony forming efficiency in soft agar in the mutant-type p53-transfected cell line (ACHN/MP) was significantly higher than that in the vector-only transfected control cell li...

Topics

Antibodies, Monoclonal
Apoptosis
Blotting, Western
Carcinoma, Renal Cell
Genes, p53
Humans
Interferon-alpha
Interferon-gamma
Interleukin-2
Kidney Neoplasms
Mutation
Transfection
Tumor Cells, Cultured
fas Receptor

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