Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Inducement effect of recombinant human TNF-alpha on apoptosis of breast cancer cell line ZR75-1 and Its mechanism].

Ai zheng = Aizheng = Chinese journal of cancer - 1 May 2006

Li Yao-Chen, Kong Ling-Hong, Li Kang-Sheng

Abstract excerpt

BACKGROUND & OBJECTIVE: Tumor necrosis factor alpha (TNF-alpha) is an important agent for tumor biotherapy because of its strong antitumor activity, but its clinical application is limited because of its severe fatal systemic toxicity. A new recombinant human (rh) mutein, mutant type (mt) 471rhTNF-alpha, was produced to decrease toxicity while keep antitumor activity of wild type (wt) TNF-alpha. This study was to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Fragmentation

Share to Mutation

Share to NF-kappa B

Share to Recombinant Proteins

Share to Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 16687074

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[Inducement effect of recombinant human TNF-alpha on apoptosis of breast cancer cell line ZR75-1 and Its mechanism].PMID 16687074Read ↗

Interferon‑α and its effects on cancer cell apoptosis (Review)Semantic proximity Read ↗

Apoptosis-Inducing TNF Superfamily Ligands for Cancer TherapySemantic proximity Read ↗

Targeting antitumor effect of rhTNF-α fusion protein mediated by matrix metalloproteinase-2.Semantic proximity Read ↗

[Combined effect of recombinant mutant human TRAIL and daunorubicin in inducing apoptosis of leukemia cell and its mechanism].Semantic proximity Read ↗

Antitumor activity of a novel recombinant mutant human tumor necrosis factor-related apoptosis-inducing ligand.Semantic proximity Read ↗

[TNF-related apoptosis-inducing ligand signaling pathway and hematopoietic malignancies].Semantic proximity Read ↗

[New insight into the mechanism of p53 inducing leukemia cell apoptosis].Semantic proximity Read ↗

Antitumor effect and mechanism of action of a tumor-targeting recombinant human tumor necrosis factor-α fusion protein mediated by urokinase.Semantic proximity Read ↗

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo.Semantic proximity Read ↗

Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1Semantic proximity Read ↗

[The relationship of p53 and the cytotoxicity mediated by TM-TNF-alpha and S-TNF-alpha].Semantic proximity Read ↗

Mutant TNFalpha negatively regulates human breast cancer stem cells from MCF7 in vitro.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.