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[New insight into the mechanism of p53 inducing leukemia cell apoptosis].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Dec 2003

Chen Yuan-zhong, Wu Yong, Liang Min, Li Nai-nong, Zhang Zhao-xiu, Lu Lian-huang

Abstract excerpt

OBJECTIVE: To investigate the expression changes of intrinsic cytokines TGF-beta(1) and TNF-alpha, telomerase activity and bcl-2 during ongoing apoptosis of HL-60 and K562 cells induced by p53. METHODS: pN53cG (Val135), a temperature sensitive p53 mutant, which behaved like wild type p53 (wt-p53) at 32.5 degrees C, were introduced into p53-null HL-60 and K562 cells respectively by lipofectin. In the presence of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 14761612

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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