Article
[Correlation of cytotoxic activity of mutant forms of tumor necrosis factor alpha with changes in the level of free sphingosine in murine liver].
Biokhimiia (Moscow, Russia) - 1 Aug 1995
Solov'ev A S, Korobko V G, Shingarova L N, Vasil'eva S V, Makhova E V, Alesenko A V
Abstract excerpt
Sphingosine, the product of enzymatic degradation of sphingomyelin, displays a high cytotoxic activity and is accumulated in animal organs under the action of the tumour necrosis factor (TNF alpha). To elucidate the role of sphingosine in the realization of TNF cytotoxicity, TNF mutants were obtained which differed in their cytotoxic action on L929 cells. The wild strain of TNF and the mutant having a deletion in...
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