Article
Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis.
British journal of cancer - 19 Jul 2004
Din F V N, Dunlop M G, Stark L A
Abstract excerpt
Epidemiological evidence indicates that non-steroidal anti-inflammatory drugs (NSAIDs) protect against colorectal cancer (CRC) to a greater degree than other non-gastrointestinal cancers, but the molecular basis for this difference is unknown. We previously reported that aspirin induces signal-specific I kappa B alpha degradation followed by NF kappa B nuclear translocation in CRC cells, and that this mechanism...
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