Article
Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1998
Rüschoff J, Wallinger S, Dietmaier W, Bocker T, Brockhoff G, Hofstädter F, Fishel R
Abstract excerpt
Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known cancer preventives, which have been largely attributed to their antiproliferative and apoptosis-inducing activities. In this study, we show that microsatellite instability (MSI) in colorectal cancer cells deficient for a subset of the h...
Topics
- Adaptor Proteins, Signal Transducing
- Anti-Inflammatory Agents, Non-Steroidal
- Apoptosis
- Aspirin
- Carrier Proteins
- Chemoprevention
- Clone Cells
- Cloning, Molecular
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA-Binding Proteins
- Fungal Proteins
- Humans