Article
The apoptosis-inducing effect of gastrin on colorectal cancer cells relates to an increased IEX-1 expression mediating NF-kappa B inhibition.
Oncogene - 14 Feb 2008
Sebens Müerköster S, Rausch A V, Isberner A, Minkenberg J, Blaszczuk E, Witt M, Fölsch U R, Schmitz F, Schäfer H, Arlt A
Abstract excerpt
Addressing the puzzling role of amidated gastrin(17) (G17) and the gastrin/CCKB/CCK2 receptor in colorectal carcinogenesis, we analysed potential candidate genes involved in G17-dependent NF-kappaB inhibition and apoptosis. The colorectal carcinoma cell line Colo320 overexpressing the wild-type CCK2 receptor (Colo320wt) underwent G17-induced apoptosis along with suppressed NF-kappaB activation and decreased...
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