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Article

Susceptibility for NSAIDs-induced apoptosis correlates to p53 gene status in gastric cancer cells.

Cancer investigation - 1 Nov 2008

Zhang Yan-Jie, Dai Qiang, Wu Shu-Ming, Zhu Hong-Yin, Shen Guan-Feng, Li En-Ling, Xiao Shu-Dong

Abstract excerpt

The anti-tumor effect of non-steroidal anti-inflammatory drugs (NSAIDs) remains unclear. Here, we found that the susceptibility for NSAIDs-induced apoptosis might correlate with the status of the p53 gene in gastric cancer cells. Apoptosis in gastric cancer cells expressing wild-type p53 is induced through up-regulation of bax and down-regulation of bcl-2 and that regulation of the bax-bcl-2 heterodimer may be a...

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Identifiers

PMID: 18798056
DOI: 10.1080/07357900801944872

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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