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Article

Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells

16 Dec 2005

Abstract excerpt

Folate is a B vitamin, deficiency of which appears to increase the risk of developing several malignancies including colorectal cancer. In contrast to the cancer-promoting effect of folate deficiency in normal tissues, several lines of evidence indicate that folate depletion suppresses the progression of existing neoplasms and enhance the sensitivity of cancer cells to chemotherapy. Folate mediates the transfer...

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PMID: 16361273
DOI: 10.1093/carcin/bgi312

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