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Article

Protective effect of NSAIDs on cancer and influence of COX-2 C(-765G) genotype.

Current cancer drug targets - 1 Dec 2008

Siemes C, Visser L E, Coebergh J W W, Hofman A, Uitterlinden A G, Stricker B H Ch

Abstract excerpt

PURPOSE: Inhibition of COX-2 enzymes is a frequently suggested mechanism for the beneficial effects of NSAIDs on carcinogenesis. The aim of this study was to explore the role of cumulative NSAID use on four common non-skin related cancers and modification by COX-2 G(-765)C genotype. PATIENTS AND METHODS: 7621 participants of The Rotterdam Study were included. In a mean follow up period of 10 years, 720...

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Identifiers

PMID: 19075598
DOI: 10.2174/156800908786733414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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