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Article

Celecoxib induces p53-PUMA pathway for apoptosis in human colorectal cancer cells.

Chemico-biological interactions - 22 Oct 2008

Liu Huei-Fang, Hsiao Po-Wen, Chao Jui-I

Abstract excerpt

Celecoxib, a clinical non-steroidal anti-inflammatory drug, displays anticarcinogenic and chemopreventive activities in human colorectal cancers, although the mechanisms of apoptosis by celecoxib are poorly understood. The existence of functional p53 but not securin in colorectal cancer cells was higher on the induction of cytotoxicity than the p53-mutational colorectal cancer cells following celecoxib treatment....

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Source

Identifiers

PMID: 18760266
DOI: 10.1016/j.cbi.2008.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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