Anticancer drug targets: cell cycle and checkpoint control

Abstract excerpt

Components of the cell cycle machinery are frequently altered in human cancer. Central players are the cyclin-dependent kinases (cdks), which govern the initiation, progression, and completion of cell cycle events. The scheduled activity of the cdks, which allows orderly transition between cell cycle phases, is controlled by their association with cyclins and cdk inhibitors, by their state of phosphorylation, and...

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