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DNA damage and cell cycle checkpoints

1 Feb 1996

Abstract excerpt

DNA is prone to numerous forms of damage that can injure cells and impair fitness. Cells have evolved an array of mechanisms to repair these injuries. Proliferating cells are especially vulnerable to DNA damage due to the added demands of cellular growth and division. Cell cycle checkpoints represent integral components of DNA repair that coordinate cooperation between the machinery of the cell cycle and several...

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PMID: 8641557
DOI: 10.1096/fasebj.10.2.8641557

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