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Article

Quorum-sensing antiactivator TraM forms a dimer that dissociates to inhibit TraR.

Molecular microbiology - 1 Jun 2004

Chen Guozhou, Malenkos James W, Cha Mee-Rye, Fuqua Clay, Chen Lingling

Abstract excerpt

The quorum-sensing transcriptional activator TraR of Agrobacterium tumefaciens, which controls the replication and conjugal transfer of the tumour-inducing (Ti) virulence plasmid, is inhibited by the TraM antiactivator. The crystal structure of TraM reveals this protein to form a homodimer in which the monomer primarily consists of two long coiled alpha-helices, and one of the helices from each monomer also...

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Share to Agrobacterium tumefaciens
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Source

Identifiers

PMID: 15186414
DOI: 10.1111/j.1365-2958.2004.04110.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Quorum-sensing antiactivator TraM forms a dimer that dissociates to inhibit TraR.PMID 15186414Read ↗

Crystal structure of the quorum-sensing protein TraM and its interaction with the transcriptional regulator TraR.Semantic proximity Read ↗

The antiactivator TraM interferes with the autoinducer-dependent binding of TraR to DNA by interacting with the C-terminal region of the quorum-sensing activator.Semantic proximity Read ↗

Identification of amino acid residues of the Agrobacterium tumefaciens quorum-sensing regulator TraR that are critical for positive control of transcription.Semantic proximity Read ↗

The quorum sensing transcriptional regulator TraR has separate binding sites for DNA and the anti-activator.Semantic proximity Read ↗

Amino-terminal protein fusions to the TraR quorum-sensing transcription factor enhance protein stability and autoinducer-independent activity.Semantic proximity Read ↗

Domains formed within the N-terminal region of the quorum-sensing activator TraR are required for transcriptional activation and direct interaction with RpoA from agrobacterium.Semantic proximity Read ↗

Dual control of quorum sensing by two TraM-type antiactivators in Agrobacterium tumefaciens octopine strain A6.Semantic proximity Read ↗

Mutational analysis of TraM correlates oligomerization and DNA binding with autoregulation and conjugative DNA transfer.Semantic proximity Read ↗

Structural basis of cooperative DNA recognition by the plasmid conjugation factor, TraM.Semantic proximity Read ↗

N- and C-terminal regions of the quorum-sensing activator TraR cooperate in interactions with the alpha and sigma-70 components of RNA polymerase.Semantic proximity Read ↗

Error-prone PCR mutagenesis reveals functional domains of a bacterial transcriptional activator, TraJ.Semantic proximity Read ↗

Identification of amino acid residues of the pheromone-binding domain of the transcription factor TraR that are required for positive control.Semantic proximity Read ↗

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