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Article

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice.

The Journal of biological chemistry - 13 Aug 2004

Furuyama Tatsuo, Kitayama Kazuko, Shimoda Yuri, Ogawa Minetaro, Sone Kiyoaki, Yoshida-Araki Kiyomi, Hisatsune Hiroshi, Nishikawa Shin-ichi, Nakayama Keiko, Nakayama Keiichi, Ikeda Kyoji, Motoyama Noboru, Mori Nozomu

Abstract excerpt

Members of the Foxo family, Foxo1 (Fkhr), Foxo3 (Fkhrl1), and Foxo4 (Afx), are mammalian homologs of daf-16, which influences life span and energy metabolism in Caenorhabditis elegans. Mammalian FOXO proteins also play important roles in cell cycle arrest, apoptosis, stress resistance, and energy metabolism. In this study, we generated Foxo1-deficient mice to investigate the physiological role of FOXO1. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Endothelium, Vascular

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Neovascularization, Pathologic

Share to Vascular Endothelial Growth Factor A

Source

Identifiers

PMID: 15184386
DOI: 10.1074/jbc.M314214200

Genes

FOXO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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