Article
Ischemia is not required for arteriogenesis in zebrafish embryos.
Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2007
Gray Caroline, Packham Ian M, Wurmser François, Eastley Nicholas C, Hellewell Paul G, Ingham Philip W, Crossman David C, Chico Timothy J A
Abstract excerpt
OBJECTIVE: The role of ischemia in collateral vessel development (arteriogenesis) is a contentious issue that cannot be addressed using mammalian models. To investigate this, we developed models of arteriogenesis using the zebrafish embryo, which gains sufficient oxygenation via diffusion to prevent ischemia in response to arterial occlusion. METHODS AND RESULTS: We studied gridlock mutant embryos that suffer a...
Topics
- Animals
- Animals, Genetically Modified
- Aortic Diseases
- Arterial Occlusive Diseases
- Arteries
- Basic Helix-Loop-Helix Transcription Factors
- Cell Hypoxia
- Collateral Circulation
- Disease Models, Animal
- Hypoxia-Inducible Factor 1, alpha Subunit
- Ischemia
- Microscopy, Confocal