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Article

Ischemia is not required for arteriogenesis in zebrafish embryos.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2007

Gray Caroline, Packham Ian M, Wurmser François, Eastley Nicholas C, Hellewell Paul G, Ingham Philip W, Crossman David C, Chico Timothy J A

Abstract excerpt

OBJECTIVE: The role of ischemia in collateral vessel development (arteriogenesis) is a contentious issue that cannot be addressed using mammalian models. To investigate this, we developed models of arteriogenesis using the zebrafish embryo, which gains sufficient oxygenation via diffusion to prevent ischemia in response to arterial occlusion. METHODS AND RESULTS: We studied gridlock mutant embryos that suffer a...

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Source

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Identifiers

PMID: 17656667
DOI: 10.1161/ATVBAHA.107.143990
PMCID: PMC2517163

Genes

GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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