Article
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.
Proceedings of the National Academy of Sciences of the United States of America - 2 Mar 2004
Hosaka Taisuke, Biggs William H, Tieu David, Boyer Antonia D, Varki Nissi M, Cavenee Webster K, Arden Karen C
Abstract excerpt
Genetic analysis in Caenorhabditis elegans has uncovered essential roles for DAF-16 in longevity, metabolism, and reproduction. The mammalian orthologs of DAF-16, the closely-related FOXO subclass of forkhead transcription factors (FKHR/FOXO1, FKHRL1/FOXO3a, and AFX/FOXO4), also have important roles in cell cycle arrest, apoptosis and stress responses in vitro, but their in vivo physiological roles are largely...
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