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Article

Association of specific haplotypes of D2 dopamine receptor gene with vulnerability to heroin dependence in 2 distinct populations.

Archives of general psychiatry - 1 Jun 2004

Xu Ke, Lichtermann Dirk, Lipsky Robert H, Franke Petra, Liu Xiehe, Hu Ying, Cao Liping, Schwab Sibylle G, Wildenauer Dieter B, Bau Claiton H D, Ferro Erica, Astor Will, Finch Thembi, Terry Jeanietta, Taubman Julie, Maier Wolfgang, Goldman David

Abstract excerpt

CONTEXT: Dopamine receptor-mediated pathways play critical roles in the mechanism of addiction. However, associations of the D(2) dopamine receptor gene (DRD2) with substance abuse are controversial. OBJECTIVE: To determine whether susceptibility sites resided at DRD2. DESIGN: Haplotype-based case-control analysis of 2 distinct populations using 10 single nucleotide polymorphisms (SNPs) with heroin dependence....

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Identifiers

PMID: 15184239
DOI: 10.1001/archpsyc.61.6.597

Genes

DRD2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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