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Article

A common mutation of the MYH gene is associated with increased DNA oxidation and age-related diseases.

Free radical biology & medicine - 1 Feb 2010

Sun Caixia, Chen Huimei, Guo Wenwen, Zhang Kui, Qi Qiufeng, Gu Xin, Zhu Dalong, Wang Yaping

Abstract excerpt

We describe a common mutation of the MYH gene, which is involved in the repair of oxidative damage to DNA, and its relationship to age, levels of 8-OHdG, and circulating levels of interleukin-1. We studied 1146 "healthy" and 562 unselected Chinese subjects. We observed a reverse insertion of the AluYb8 sequence (AluYb8MYH) to be homozygous in approximately 25.8% of the healthy Chinese population age 20-29 years,...

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Identifiers

PMID: 19932167
DOI: 10.1016/j.freeradbiomed.2009.11.015

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