Article
Association of interleukin-10 promoter polymorphism with the incidence of multiple organ dysfunction following major trauma: results of a prospective pilot study.
Shock (Augusta, Ga.) - 1 Apr 2004
Schröder Ove, Laun Reinhold Alexander, Held Burkhard, Ekkernkamp Axel, Schulte Klaus-Martin
Abstract excerpt
A dysbalanced immune response is thought to account for a substantial part of the morbidity and mortality after severe trauma. The cytokine interleukin-10 (IL-10) suppresses the transcription of proinflammatory cytokines, mainly in macrophages and monocytes. The objectives of this prospective study in a level I trauma center in Germany were to examine the distribution of IL-10 promoter polymorphisms in a cohort...
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