Article
Clinical relevance of the interleukin 10 promoter polymorphisms in Chinese Han patients with major trauma: genetic association studies.
Critical care (London, England) - 1 Jan 2009
Zeng Ling, Gu Wei, Chen Kehong, Jiang Dongpo, Zhang Lianyang, Du Dingyuan, Hu Ping, Liu Qing, Huang Suna, Jiang Jianxin
Abstract excerpt
INTRODUCTION: An excessive inflammatory response is thought to account for the pathogenesis of sepsis and multiple organ dysfunction syndrome (MODS) after severe trauma. The interleukin-10 (IL-10) is a potent anti-inflammatory cytokine. The objectives of this prospective study were to investigate the distribution of IL-10 promoter polymorphisms in a cohort of 308 Chinese Han patients with major trauma, and to...
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