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Article

VEGF: necessary to prevent motoneuron degeneration, sufficient to treat ALS?

Trends in molecular medicine - 1 Jun 2004

Lambrechts Diether, Storkebaum Erik, Carmeliet Peter

Abstract excerpt

Since Charcot recognized the devastating disorder amyotrophic lateral sclerosis (ALS) in 1874, many theories have been proposed to explain its pathogenesis, but it remains as deadly and incurable as ever. Three years ago it was reported that reduced levels of vascular endothelial growth factor (VEGF) caused ALS-like motoneuron degeneration in mice. Recent evidence indicates that insufficient VEGF is also a risk...

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Identifiers

PMID: 15177192
DOI: 10.1016/j.molmed.2004.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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