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Article

Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish.

Human molecular genetics - 1 Oct 2007

Lemmens Robin, Van Hoecke Annelies, Hersmus Nicole, Geelen Veerle, D'Hollander Isabel, Thijs Vincent, Van Den Bosch Ludo, Carmeliet Peter, Robberecht Wim

Abstract excerpt

The development of small animal models is of major interest to unravel the pathogenesis and treatment of neurodegenerative diseases, especially because of their potential in large-scale chemical and genetic screening. We have investigated the zebrafish as a model to study amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by the selective loss of motor neurons, caused by...

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PMID: 17636250
DOI: 10.1093/hmg/ddm193

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SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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