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Article

Granulocyte-colony stimulating factor improves outcome in a mouse model of amyotrophic lateral sclerosis.

Brain : a journal of neurology - 1 Dec 2008

Pitzer Claudia, Krüger Carola, Plaas Christian, Kirsch Friederike, Dittgen Tanjew, Müller Ralph, Laage Rico, Kastner Stefan, Suess Stefanie, Spoelgen Robert, Henriques Alexandre, Ehrenreich Hannelore, Schäbitz Wolf-Rüdiger, Bach Alfred, Schneider Armin

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease that results in progressive loss of motoneurons, motor weakness and death within 1-5 years after disease onset. Therapeutic options remain limited despite a substantial number of approaches that have been tested clinically. In particular, various neurotrophic factors have been investigated. Failure in these trials has been largely...

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Identifiers

PMID: 18835867
DOI: 10.1093/brain/awn243
PMCID: PMC2639207

Genes

SOD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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