Article
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death.
Nature genetics - 1 Aug 2003
Lambrechts Diether, Storkebaum Erik, Morimoto Masafumi, Del-Favero Jurgen, Desmet Frederik, Marklund Stefan L, Wyns Sabine, Thijs Vincent, Andersson Jörgen, van Marion Ingrid, Al-Chalabi Ammar, Bornes Stephanie, Musson Rhiannon, Hansen Valerie, Beckman Lars, Adolfsson Rolf, Pall Hardev Singh, Prats Hervé, Vermeire Severine, Rutgeerts Paul, Katayama Shigehiro, Awata Takuya, Leigh Nigel, Lang-Lazdunski Loïc, Dewerchin Mieke, Shaw Christopher, Moons Lieve, Vlietinck Robert, Morrison Karen E, Robberecht Wim, Van Broeckhoven Christine, Collen Désiré, Andersen Peter M, Carmeliet Peter
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is an incurable degenerative disorder of motoneurons. We recently reported that reduced expression of Vegfa causes ALS-like motoneuron degeneration in Vegfa(delta/delta) mice. In a meta-analysis of over 900 individuals from Sweden and over 1,000 individuals from Belgium and England, we now report that subjects homozygous with respect to the haplotypes -2,578A/-1,154A/-634G or...
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