Article
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype.
Journal of medical genetics - 1 Dec 2009
Lambrechts D, Poesen K, Fernández-Santiago R, Al-Chalabi A, Del Bo R, Van Vught P W J, Khan S, Marklund S L, Brockington A, van Marion I, Anneser J, Shaw C, Ludolph A C, Leigh N P, Comi G P, Gasser T, Shaw P J, Morrison K E, Andersen P M, Van den Berg L H, Thijs V, Siddique T, Robberecht W, Carmeliet P
Abstract excerpt
BACKGROUND: Targeted delivery of the angiogenic factor, vascular endothelial growth factor (VEGF), to motor neurons prolongs survival in rodent models of amyotrophic lateral sclerosis (ALS), while mice expressing reduced VEGF concentrations develop motor neuron degeneration reminiscent of ALS, raising the question whether VEGF contributes to the pathogenesis of ALS. An initial association study reported that VEGF...
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