Article
Ubc9 is required for damage-tolerance and damage-induced interchromosomal homologous recombination in S. cerevisiae.
DNA repair - 4 Mar 2004
Maeda Daisuke, Seki Masayuki, Onoda Fumitoshi, Branzei Dana, Kawabe Yoh-Ichi, Enomoto Takemi
Abstract excerpt
Ubc9 is an enzyme involved in the conjugation of small ubiquitin related modifier (SUMO) to target proteins. A Saccharomyces cerevisiae ubc9 temperature sensitive (ts) mutant showed higher sensitivity to various DNA damaging agents such as methylmethanesulfonate (MMS) and UV at a semi-permissive temperature than wild-type cells. The sensitivity of ubc9ts cells was not suppressed by the introduction of a mutated...
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