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Article

Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.

Anesthesiology - 1 Feb 2003

Topf Norbert, Jenkins Andrew, Baron Nicole, Harrison Neil L

Abstract excerpt

BACKGROUND: Volatile anesthetics prolong inhibitory postsynaptic potentials in central neurons an allosteric action on the gamma-aminobutyric acid type A (GABA(A)) receptor, an effect that may underlie the hypnotic actions of these agents. Inhaled anesthetics such as isoflurane act to enhance responses to submaximal concentrations of GABA, but it is not clear whether their effect is mediated by an increase in the...

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Source

Identifiers

PMID: 12552186
DOI: 10.1097/00000542-200302000-00007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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