Article
Determinants of the anesthetic sensitivity of neuronal nicotinic acetylcholine receptors.
The Journal of biological chemistry - 22 Mar 2002
Downie David Lindsay, Vicente-Agullo Francisco, Campos-Caro Antonio, Bushell Trevor John, Lieb William Robert, Franks Nicholas Peter
Abstract excerpt
Some neurotransmitter-gated ion channels are very much more sensitive to general anesthetics than others, even when they are genetically and structurally related. The most striking example of this is the extreme sensitivity of heteromeric neuronal nicotinic acetylcholine receptors to inhalational general anesthetics compared with the marked insensitivity of the closely related homomeric neuronal nicotinic...
Topics
- Acetylcholine
- Anesthetics, Inhalation
- Animals
- Dose-Response Relationship, Drug
- Female
- Halothane
- Mutagenesis, Site-Directed
- Mutation
- Neurons
- Oocytes
- Protein Binding
- Protein Structure, Tertiary
- Receptors, Nicotinic
- Recombinant Fusion Proteins