Article
Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and -gamma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2004
Benimetskaya Luba, Wittenberger Timo, Stein C A, Hofmann Hans-Peter, Weller Claudia, Lai Johnathan C, Miller Paul, Gekeler Volker
Abstract excerpt
PURPOSE: G3139 is an antisense bcl-2 phosphorothioate oligodeoxyribonucleotide that is currently being evaluated in Phase III clinical trials in several human cancers. The aim of the present work was to further identify the apparent non-bcl-2-dependent mechanism of this action of this compound in PC3 prostate cancer cells. EXPERIMENTAL DESIGN: We performed Affymetrix U95A oligonucleotide microarray studies on...
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