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MicroRNAs as potential therapeutics to enhance chemosensitivity in advanced prostate cancer

14 May 2018

Abstract excerpt

Docetaxel and cabazitaxel are taxane chemotherapy treatments for metastatic castration-resistant prostate cancer (CRPC). However, therapeutic resistance remains a major issue. MicroRNAs are short non-coding RNAs that can silence multiple genes, regulating several signalling pathways simultaneously. Therefore, synthetic microRNAs may have therapeutic potential in CRPC by regulating genes involved in taxane...

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PMID: 29777112
DOI: 10.1038/s41598-018-26050-y

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