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Article

Ribozyme-mediated inhibition of PKCalpha sensitizes androgen-independent human prostate cancer cells to cisplatin-induced apoptosis.

The Prostate - 1 Feb 2003

Orlandi Linda, Binda Mara, Folini Marco, Bearzatto Alessandra, Villa Raffaella, Daidone Maria Grazia, Zaffaroni Nadia

Abstract excerpt

BACKGROUND: Therapeutic strategies to target the molecular basis of hormone and drug resistance of prostate cancer cells are needed. Since protein kinase Calpha (PKCalpha) is thought to have a role in the development of the androgen-independent phenotype of prostate cancer cells and in apoptosis suppression, the objective of the present study was to test whether specific inhibition of PKCalpha by a hammerhead...

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PMID: 12497586
DOI: 10.1002/pros.10181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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