Article

Polypyrimidine Tract-Binding Protein 1 (PTBP1) regulates CD4 T cell Activation independent of its role in proliferation

2022-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Our previous work found that the RNA binding protein polypyrimidine tract-binding protein (PTBP1) is critical for regulating multiple events in T cell activation including changes in proliferation, and expression of activation markers and cytokines. These changes corresponded to the regulation of the ERK1/2 and NF-κB pathways as well as through changes in steady-state RNA levels. Because prolife...

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Literature Corpus work: c0fda47c-1195-57d7-819f-3d2b71fe8904
DOI: 10.1101/2022.03.21.485057

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