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Article

Transcriptional signature of flavopiridol-induced tumor cell death

1 Jul 2004

Abstract excerpt

Flavopiridol has been shown to inhibit the proliferation of a variety of human tumor cells and is currently undergoing clinical evaluation in cancer treatment. Although the antiproliferative effect of flavopiridol has been attributed to the inhibition of cyclin-dependent kinases 2 and 4, recent reports indicate that the mechanism responsible for the cell death induced by this agent is more complex. To provide...

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PMID: 15252147
DOI: 10.1158/1535-7163.861.3.7

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