Article
Transcriptional and translational control of ornithine decarboxylase during Ras transformation.
The Biochemical journal - 1 Jan 2004
Shantz Lisa M
Abstract excerpt
ODC (ornithine decarboxylase) activity is induced following ras activation. However, the Ras effector pathways responsible are unknown. These experiments used NIH-3T3 cells expressing partial-loss-of-function Ras mutants to activate selectively pathways downstream of Ras and examined the contribution of each pathway to ODC induction. Overexpression of Ras12V, a constitutively active mutant, resulted in ODC...
Topics
- Animals
- Cell Line, Transformed
- Enzyme Inhibitors
- Gene Expression Regulation
- Mice
- Mutation
- NIH 3T3 Cells
- Ornithine Decarboxylase
- Protein Biosynthesis
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins p21(ras)