Article
Transcriptional and translational control of ornithine decarboxylase during Ras transformation.
The Biochemical journal - 1 Jan 2004
Shantz Lisa M
Abstract excerpt
ODC (ornithine decarboxylase) activity is induced following ras activation. However, the Ras effector pathways responsible are unknown. These experiments used NIH-3T3 cells expressing partial-loss-of-function Ras mutants to activate selectively pathways downstream of Ras and examined the contribution of each pathway to ODC induction. Overexpression of Ras12V, a constitutively active mutant, resulted in ODC...
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