Article

Oncogenic mutations convert MET from a pro-apoptotic tumor suppressor to an oncogenic driver

2025-11-11

Abstract excerpt

<h4>SUMMARY</h4> Dependence receptors can exert both oncogenic and tumor-suppressive activities. In cancers, downregulation of dependence receptors or overexpression of their ligands are well-established mechanisms that drive tumor progression. However, direct genetic alterations abolishing the pro-apoptotic function of dependence receptors have not been documented so far. MET, a receptor tyrosine kinase classica...

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Literature Corpus work: e57a3648-06bf-5859-8570-ed45673a201d
DOI: 10.1101/2025.11.10.687614

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