Article
Colorectal cancer without high microsatellite instability and chromosomal instability--an alternative genetic pathway to human colorectal cancer.
Carcinogenesis - 1 May 2004
Tang Reiping, Changchien Chung Rong, Wu Meng-Chih, Fan Chung-Wei, Liu Kwang-Wen, Chen Jinn-Shiun, Chien Huei-Tzu, Hsieh Ling-Ling
Abstract excerpt
At least two forms of genomic instability have been described in colorectal cancers (CRCs): microsatellite instability (MIN), which is characterized by a high frequency of microsatellite instability (MSI-H) and chromosomal instability (CIN), which is characterized by losses and gains of chromosomes (aneuploidy), as well as chromosome rearrangements. Morphological and molecular heterogeneity within MIN(-) CRCs...
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