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Article

Lynch Syndrome (HNPCC) and Microsatellite Instability

1 Jan 2004

Abstract excerpt

A departure from the concept of simple adenoma to carcinoma sequence is the realization that colorectal cancer (CRC) develops through at least two major molecular pathogenic pathways, namely chromosomal instability (CIN) and microsatellite instability (MSI) [1,2]. The mechanisms underlying CIN might have been the first to be deciphered but they are just being understood in detail. It is proposed that CIN may be...

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Identifiers

PMID: 15528783
DOI: 10.1155/2004/486032

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