Article
Confirmation and dissection of QTL controlling resistance to malaria in mice.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2004
Hernandez-Valladares Maria, Naessens Jan, Gibson John P, Musoke Anthony J, Nagda Sonal, Rihet Pascal, Ole-MoiYoi Onesmo K, Iraqi Fuad A
Abstract excerpt
We developed an F(11) AIL population from an F(1) cross of A/J (susceptible) and C57BL/6J (resistant) mouse strains. One thousand F(11) mice were challenged with P.c. chabaudi 54X, and 340 mice selected from the phenotypic extremes for susceptibility and resistance were genotyped for microsatellite markers on Chromosomes (Chrs) 5, 8, and 17. QTL originally detected in backcross and F(2) populations were confirmed...
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