Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.

doi:10.1016/s1074-7613(00)80343-x

Back to search

Article

Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.

Immunity - 1 May 1997

Beebe A M, Mauze S, Schork N J, Coffman R L

Abstract excerpt

Resistance or susceptibility of inbred mouse strains to the parasite Leishmania major correlates with CD4+ T cell responses of the Th1 or Th2 subsets, respectively. To evaluate the genetic basis for this difference, resistant B10.D2 mice were backcrossed onto susceptible BALB/c mice for five gene...

Topics

Animals
Chromosome Mapping
Crosses, Genetic
Disease Susceptibility
Female
Genotype
Immunity, Innate
Leishmania major
Leishmaniasis, Cutaneous
Linkage Disequilibrium
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Pedigree
Phenotype
Probability

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.