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Article

Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice.

Immunity - 1 May 1997

Beebe A M, Mauze S, Schork N J, Coffman R L

Abstract excerpt

Resistance or susceptibility of inbred mouse strains to the parasite Leishmania major correlates with CD4+ T cell responses of the Th1 or Th2 subsets, respectively. To evaluate the genetic basis for this difference, resistant B10.D2 mice were backcrossed onto susceptible BALB/c mice for five generations with selection for resistance. Candidate resistance loci were identified by high frequency of heterozygosity in...

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PMID: 9175833
DOI: 10.1016/s1074-7613(00)80343-x

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