Article
Asymmetric limb malformations in a new transgene insertional mutant, footless.
Mechanisms of development - 1 May 2003
Bell Sheila M, Schreiner Claire M, Hess Karla A, Anderson Kathleen P, Scott William J
Abstract excerpt
Six to eight copies of a transgene integrated into mouse chromosome 15 resulting in a new transgene insertional mutant, Footless, presenting with malformations of the limbs, kidney, and soft palate. Homozygotes possess a unique asymmetric pattern of limb truncations. Posterior structures from the autopod and zeugopod of the hindlimbs are missing with left usually more severely affected than right. In contrast,...
Topics
- Animals
- Blotting, Southern
- Cleft Palate
- DNA-Binding Proteins
- Extremities
- Female
- Fibroblast Growth Factor 8
- Fibroblast Growth Factors
- Genotype
- Heterozygote
- Homeodomain Proteins
- Homozygote
- In Situ Hybridization
- Kidney
- Limb Deformities, Congenital
- Mice
- Models, Genetic
- Mutation