Article
Frequency of CARD15 polymorphisms in patients with Crohn's disease from Toledo, Spain: genotype-phenotype correlation.
Genetic testing - 1 Jan 2006
De Diego Carles, Alcántara Mariano, Valle Julio, Pérez-Grueso María José, Muñoz-Rosas Concepción, Carrobles José María, Martínez-Castro Pedro
Abstract excerpt
Crohn's disease (CD) presents a complex multifactorial etiology with genetic and environmental factors contributing to the disorder. Epidemiological studies have shown that three major CARD15 polymorphisms, R702W, G908R, and 1007fs, are associated with CD. We studied the frequencies of these three polymorphisms in patients from Toledo, Spain, and compared them with the frequencies found in studies of other...
Topics
- Adult
- Amino Acid Substitution
- Crohn Disease
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Nod2 Signaling Adaptor Protein
- Phenotype
- Polymorphism, Genetic